This conclusion may reflect a subclinical effect of bone lead stores on hematopoiesis and is the first epidemiological evidence that bone lead may be an important biological marker of ongoing chronic toxicity. We conclude that patella bone lead levels are associated with decreased hematocrit and hemoglobin levels despite the presence of low blood lead levels.
In the final multivariate regression model that corrected for measurement error, an increase in patella bone lead level from the lowest to highest quintile in this study population (37 micrograms/g) was associated with a decrease in hemoglobin and hematocrit of 11 g/L (95% confidence interval, 2.7 to 19.3 g/L) and 0.03 (95% CI, 0.01 to 0.05), respectively. Recently, two large randomized, controlled trials of the Correction of Hemoglobin and Outcomes in Renal Insuffiency (CHOIR) conducted in predialysis patients with CKD stages 3 or 4 found that targeting a high Hb level (13.5 g/dl) was associated with increased risk of composite events (including death and stroke) compared with low Hb target (11. Blood lead levels were low (mean = 0.40 mumol/L ) and were not correlated with either hemoglobin or hematocrit. Information was also collected on medical history, smoking, and alcohol ingestion.īone lead levels in the patella were found to be significantly correlated with a decrease in hemoglobin and hematocrit, even after adjusting for age, blood lead, body mass index, cigarette smoking, and alcohol ingestion and removing outliers. We measured blood lead by anodic stripping voltametry and used a cadmium 109 K x-ray fluorescence instrument to make in vivo measurements of lead in the tibia (a heavily cortical bone) and the patella (a heavily trabecular bone). We measured blood pressure, serum creatinine, hematocrit, and hemoglobin. To determine whether the concentration of lead in bone constitutes a biological marker that is more sensitive for chronic toxicity than blood lead levels.Ī construction trade union with members who engage in carpentry, demolition, and other construction activities.
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